Histamine Intolerance Part 3: Treatment of Histamine Intolerance

By Lindsay Christensen

Nutritionist @ The Pratt Clinics


Now that I’ve discussed the underlying causes of histamine intolerance, let’s dig into treatment options! Usually, a combination of dietary, nutritional, and lifestyle interventions can make a significant difference in symptoms when it comes to histamine intolerance. I recommend starting with dietary changes. 

Eat a low-histamine diet 

The first step in correcting histamine intolerance is to follow a low-histamine diet for at least six weeks; this will give your body sufficient time to clear excess histamine and dampen inflammation. Here are my guidelines for a low-histamine diet: 

High-histamine foods to avoid:

Microbiologically-produced foods: Yogurt, buttermilk, kefir, mature cheese, sauerkraut, kimchi, pickles, kombucha, soy sauce, fish sauce, black tea, coffee, chocolate
Processed, smoked, and fermented meats: Sausage, pepperoni, salami
Alcohol: Red wine, white wine, champagne, cider, beer
Yeasty foods: Bread 
Spinach, tomatoes, citrus fruits, strawberries, kiwi, pineapple, avocado
Peanuts, cashews, walnuts 
Canned, smoked, or fermented seafood
Eggs (are only problematic for some histamine-intolerant people)

Focus on eating the following low-histamine foods: 

Organic meats and poultry, fresh fish 
Vegetables: Squash, leafy greens, cruciferous vegetables, carrots, onions, shallots, sweet potatoes, turnips, zucchini
Fruits: Apples, nectarines, berries, watermelon
Fats: olive oil, coconut oil, ghee, coconut butter
Gluten-free grains: Quinoa, rice, buckwheat
Legumes: Chickpeas, lentils, kidney beans (ideally, these should be fresh rather than canned)

The key to eating a low-histamine diet is to choose fresh foods. Even leftovers can be problematic for some people because the longer cooked food sits in the fridge, the more opportunity there is for bacteria to grow in the food and produce histamine as a byproduct. 

In addition to eating fresh foods, add foods and herbs with natural antihistamine properties to your diet. Here’s a list of my favorite natural antihistamine foods:

Watercress (1) 
Apples (2)  
Pomegranate (3) 
Ginger (4)  
Pea sprouts (5)  
Onion (6)  
Garlic (7)  
Thyme (8)  
Tarragon (9) 
Black cumin seed oil (10) 

Repair leaky gut and correct gut dysbiosis

The treatment of leaky gut and intestinal dysbiosis with probiotics and antimicrobials can be a game-changer in the mission to resolve histamine intolerance. I recommend ProBiota HistaminX, a probiotic that supports histamine degradation because it contains histamine-degrading bacteria. It is well-tolerated by histamine-sensitive individuals. Soil-based microorganisms, which are often histamine neutral or histamine degrading, are also beneficial because they can reduce bacterial overgrowth and repair leaky gut. 

Optimize methylation and gene expression

As I mentioned in Part 1, methylation is a crucial pathway for breaking down histamine. Correcting deficiencies of nutrients involved in methylation can help optimize gene expression and enhance histamine degradation. The nutrients needed to optimize methylation in your body will depend on your unique genetic profile. However, there are a few nutritional rules of thumb that can help ensure you are getting enough methylation-supportive nutrients in your diet.

Eat dark leafy greens: These are a rich source of methylfolate, which is a crucial cofactor in the methylation cycle. Folate is also found in legumes, such as chickpeas and lentils, and beef liver.

Eat B12-rich foods: Vitamin B12 is found almost exclusively in animal foods such as red meat, chicken, turkey, and seafood. The two exceptions are purple laver, a type of seaweed, and wild mushroom such as chanterelle, black trumpet, and shiitake mushrooms, which contain active B12 compounds. 

Eat choline-rich foods: Choline is a vitamin-like essential nutrient that is converted into betaine in the body. Betaine is a key part of the methylation cycle. The foods richest in choline are egg yolks and beef liver. Nuts and cruciferous vegetables (broccoli, cauliflower) also contain choline, but you need to eat at least 200 g to get the same amount of choline as 1 egg yolk. 

Diversify your protein intake: Animal proteins such as poultry, red meat, fish, eggs, and dairy supply methionine. an amino acid needed for the methylation cycle. 

Eating the foods discussed above will provide you with all the nutrients needed for methylation. However, if you want to learn how to support your unique genetic snps, consider speaking with Dr. Pratt who specializes in the topic.

Clean up your environment

Make sure your living and work environments are clean and free of allergens and other inflammatory substances, such as mold. If you know your home has sustained water damage or suspect a mold problem, I first recommend doing an ERMI (Environmental Relative Moldiness) test. You can order the test through Mycometrics. 

Some other steps you can take to clean up your environment include putting dust mite covers on pillows and mattresses, getting your air ducts cleaned, and investing in a high-quality air purifier such as an IQ Air machine. 

Take natural antihistamines 

There are a variety of natural substances that can help ease the symptoms of histamine intolerance without the side effects associated with pharmaceutical antihistamines. 

• DAO enzymes such as those found in Histamine Block, are especially helpful for preventing and reducing food-induced histamine reactions. 
• Quercetin is a phytonutrient found in fruits, vegetables, and herbs that is a potent anti-inflammatory and natural antihistamine. (11)  
• Vitamin C destroys the ring-shaped structure of the histamine molecule, and thus serves as a natural antihistamine. (12) I recommend taking vitamin C as a supplement and getting it in your diet from low-histamine fruits and vegetables such as kiwi, raspberries, blueberries, watermelon, broccoli, kale, and cauliflower. 
• Stinging nettle is an herb that has anti-inflammatory and antihistamine properties. (13) 
• Moringa stabilizes mast cells (immune cells that release histamine). (14) 
• Holy Basil is a mast cell stabilizer and antihistamine. (15) 
• Cat’s Claw modulates the immune system and may help quench the inflammatory response that contributes to histamine intolerance.

Histamine Intolerance may seem a little overwhelming and confusing. That is why The Pratt Clinics are always here to help. Please contact us with any questions or to schedule an appointment.


Constituents in Watercress : Inhibitors of Histamine Release from RBL-2H3 Cells Induced by Antigen Stimulation.
Inhibitory Effects of Apple Polyphenol on Induced Histamine Release from RBL-2H3 Cells and Rat Mast Cells.
Polyphenol-rich pomegranate fruit extract (POMx) suppresses PMACI-induced expression of pro-inflammatory cytokines by inhibiting the activation of MAP Kinases and NF-κB in human KU812 cells.
Antiallergic Potential on RBL-2H3 Cells of Some Phenolic Constituents of Zingiber officinale (Ginger).
Pea Seedling Histaminase as a Novel Therapeutic Approach to Anaphylactic and Inflammatory Disorders. 
Anti-Allergic Effects of Herbal Product from Allium cepa (Bulb). 
Inhibitory Action of Allicin on Degranulation of Mast Cells Produced by Compound 48/80, Histamine Liberator from Ascaris, Lecithinase A, and Antigen.
Coumarin and Flavone Derivatives from Estragon and Thyme as Inhibitors of Chemical Mediator Release from RBL-2H3 Cells. 
Coumarin and Flavone Derivatives from Estragon and Thyme as Inhibitors of Chemical Mediator Release from RBL-2H3 Cells.
The antioxidative and antihistaminic effect of Nigella sativa and its major constituent, thymoquinone on ethanol-induced gastric mucosal damage. 
Quercetin, Inflammation and Immunity.
Antihistamine effects and complications of supplemental vitamin C. 
Nettle extract (Urtica dioica) affects key receptors and enzymes associated with allergic rhinitis. 
Investigation into the mechanism of action of Moringa oleifera for its anti-asthmatic activity. 
Pharmacological Basis For Antianaphylactic, Antihistaminic And Mast Cell Stabilization Activity Of Ocimum Sanctum. 

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